Lurasidone compared to other atypical antipsychotic monotherapies for adolescent schizophrenia: a systematic literature review and network meta-analysis

Abstract

This network meta-analysis assessed the efficacy and tolerability of lurasidone versus other oral atypical antipsychotic monotherapies in adolescent schizophrenia. A systematic literature review identified 13 randomized controlled trials of antipsychotics in adolescents with schizophrenia-spectrum disorders. A Bayesian network meta-analysis compared lurasidone to aripiprazole, asenapine, clozapine, olanzapine, paliperidone extended-release (ER), quetiapine, risperidone, and ziprasidone. Outcomes included Positive and Negative Syndrome Scale (PANSS), Clinical Global Impressions-Severity (CGI-S), weight gain, all-cause discontinuation, extrapyramidal symptoms (EPS), and akathisia. Results were reported as median differences for continuous outcomes and odds ratios (ORs) for binary outcomes, along with 95% credible intervals (95% CrI). Lurasidone was significantly more efficacious than placebo on the PANSS (−\u20097.95, 95% CrI −\u200911.76 to −\u20094.16) and CGI-S (−\u20090.44, 95% CrI −\u20090.67 to −\u20090.22) scores. Lurasidone was associated with similar weight gain to placebo and statistically significantly less weight gain versus olanzapine (−\u20093.62 kg, 95% CrI −\u20094.84 kg to −\u20092.41 kg), quetiapine (−\u20092.13 kg, 95% CrI −\u20093.20 kg to −\u20091.08 kg), risperidone (−\u20091.16 kg, 95% CrI −\u20092.14 kg to −\u20090.17 kg), asenapine (−\u20090.98 kg, 95% CrI −\u20091.71 kg to −\u20090.24 kg), and paliperidone ER (−\u20090.85 kg, 95% CrI −\u20091.57 kg to −\u20090.14 kg). The odds of all-cause discontinuation were significantly lower for lurasidone than aripiprazole (OR\u2009=\u20090.28, 95% CrI 0.10–0.76) and paliperidone ER (OR\u2009=\u20090.25, 95% CrI 0.08–0.81) and comparable to other antipsychotics. Rates of EPS and akathisia were similar for lurasidone and other atypical antipsychotics. In this network meta-analysis of atypical antipsychotics in adolescent schizophrenia, lurasidone was associated with similar efficacy, less weight gain, and lower risk of all-cause discontinuation compared to other oral atypical antipsychotics.