Comparison of long-term effects of egg yolk consumption under normal and high fat diet on lipid metabolism and fatty acids profile in mice

Abstract

This study compared the long-term effects of EY consumption under two diet conditions: normal (ND\u2009+\u2009EY) and high fat diet (HFD\u2009+\u2009EY), on lipid metabolism in mice. ND\u2009+\u2009EY did not increase serum triglycerides, total cholesterol hepatic triglyceride concentrations, adipose tissue accumulation and glucose impairment, not leading to fatty liver. HFD\u2009+\u2009EY markedly decreased adipose tissue accumulation, the triglyceride and total cholesterol, and improved serum HDL-C and blood glucose impairment compared with HFD. PLS-DA analyzes showed both ND\u2009+\u2009EY and HFD\u2009+\u2009EY could decrease serum C18:1 and MUFA. HFD\u2009+\u2009EY could further decrease hepatic C18:2 and PUFA and increase C18:1 and MUFA excretion, which were associated with lower expression of Elovl6 and higher expression of Scd1 in liver. These results suggest that HFD\u2009+\u2009EY significantly improved dyslipidemia caused by HFD through modifying lipid metabolism, and ND\u2009+\u2009EY did not adversely affect the biomarkers associated with dyslipidemia risk, but showed less obvious regulation of lipid metabolism than HFD\u2009+\u2009EY.