Polysomnographic correlates of sleep disturbances in de novo, drug naïve Parkinson’s Disease

Abstract

Sleep disturbances are common non-motor symptoms of Parkinson’s Disease (PD). The aim of this study was to investigate the polysomnographic correlates of sleep changes, as investigated by the Parkinson’s Disease Sleep Scale-2 (PDSS-2), in a cohort of sixty-two consecutive de novo, drug naïve PD patients (71.40\u2009±\u20097.84 y/o). PDSS-2 total score showed a direct correlation with stage shifts (p\u2009=\u20090.008). Fragmented sleep showed an inverse correlation with sleep efficiency (p\u2009=\u20090.012). Insomnia symptoms showed an inverse correlation with wake after sleep onset (p\u2009=\u20090.005) and direct correlation with periodic leg movements (p\u2009=\u20090.006) and stage shift indices (p\u2009=\u20090.003). Motor Symptoms showed a direct correlation with Apnoea-Hypopnoea (AHI; p\u2009=\u20090.02) and awakenings indices (p\u2009=\u20090.003). Dream distressing showed a direct correlation with REM without atonia (RWA, p\u2009=\u20090.042) and an inverse correlation with AHI (p\u2009=\u20090.012). Sleep quality showed an inverse correlation with RWA (p\u2009=\u20090.008). PDSS-2 features are significantly correlated with polysomnography objective findings, thus further supporting its reliability to investigate sleep disturbances in PD patients.