Catalysis Letters | 2019
Organocatalyzed cross-dehydrogenative coupling for C(sp3)–O bonds formation: a rapid access to α-aminoxyl isochromans
Abstract
Tetrabutyl ammonium iodide catalyzed cross-dehydrogenative coupling reaction between α-C(sp3)–H of isochromans and N-hydroxyphathalimide has been achieved using tert-butylhydroxyperoxide as the\xa0terminal oxidant. This method offers rapid access to prevalent α-aminoxyl isochroman architectures. A diverse of synthetic isochromans was tolerated with this protocol, giving the corresponding product in moderate to good yields.Graphical Abstract