Hair as a noninvasive biomarker of human exposure to the endocrine disruptors polybrominated diphenyl ethers: a meta-analysis

Abstract

Several epidemiological studies with small sample sizes have suggested that hair is a promising biomarker of exposure to polybrominated diphenyl ethers (PBDEs). We reanalyzed the data from human studies to investigate correlations between the concentrations of the five main congeners in hair and serum. We searched medical article databases for articles that reported correlation coefficients for concentrations of PBDEs in hair and serum. The methodological quality of the included articles was fully assessed. Then, the correlation coefficients were used for our analysis. Seven epidemiological studies were included in our analysis using the random-effects model. Significant positive relationships were found between the concentrations of the five congeners (BDE28, BDE47, BDE99, BDE100, BDE209) in serum and hair. The results of this study show that hair may be a promising biomarker for the biomonitoring human exposure to the five congeners of PBDEs within a certain detection range. Studies with a larger sample size are needed to explore the detection range.