Functionalized Gold Nanoparticles Based Optical, Surface Plasmon Resonance-Based Sensor for the Direct Determination of Mitoxantrone Anti-cancer Agent from Real Samples

Abstract

This study represents a simple and facile method for the fabrication of gold nanoparticles (AuNPs) using Cephradine (Cep) drug as a capping agent. Synthesized Cep-AuNPs have been characterized using different modern analytical techniques such as UV–Vis spectroscopy, X-ray diffractometry, and Atomic Force Microscopy. The estimated average size of synthesized gold nanoparticles was found up to 30 nm. These Cep-AuNPs has been used for the highly selective and sensitive colorimetric sensing for the mitoxantrone (MX) detection. The linear range of proposed colorimetric sensor responded to MX in the range of 10–100 µg/L. The detection and quantification limit of the sensor was 3.5 µg/L and 11.9 µg/L, respectively. The developed sensor was highly selected and highly efficient for MX detection as compared with other coexisting compounds such as 5Florourical, Capecitabine, Methotrexate (MTX), Zoledronic Acid. This developed sensor was successfully applied for the detection of MX from the real biological samples. The developed colorimetric sensor is sensitive, selective, cheaper and no need for sample preparation and easy to operate. No need expansive instruments.