International Urology and Nephrology | 2021
Importance of eculizumab treatment in recurrence of atypical hemolytic uremic syndrome during the SARS-CoV-2 pandemic
Abstract
The pandemic of Coronavirus Disease 19 (COVID-19) continues as an important public health problem, nowadays [1]. This pandemic has affected many such chronic patients who were unable to receive their regular therapies. There is not enough information about how atypical hemolytic uremic syndrome (aHUS) cases affect the pandemic. We present a case of recurrent aHUS accompanied by severe kidney disease during the SARS-CoV-2 (Severe Acute Respiratory Syndrome causing Coronavirus) pandemic. This case also recovered exceptionally from COVID-19 pneumonia and was in remission again with eculizumab treatment in spite of serum creatinine 6.9 mg/dL. A 29-year-old female patient was being followed up in remission due to aHUS accompanying posterior reversible encephalopathy syndrome (PRES) [2]. Genetic analysis of complement protein genes was mutated at on the complement factor H (CFH –p.Glu936Asp, p.Arg1192Ile) antigen and CFHR5 genes (p.Arg356His) with associated aHUS. Her past medical history had 4-month hemodialysis treatment due to aHUS 4 years ago. She was in remission for 52 months with eculizumab treatment of 900 mg every 15 days. She admitted to another hospital with fever and cough complaints. At admission, her body temperature was 38.7 °C, oxygen saturation was 90%. Chest tomography demonstrated bilateral widespread ground glass opacities. The inflammatory involvement rate in lung parenchyma was 25%. SARS-CoV-2 test was positive by nucleic acidbased polymerase chain reaction in throat swabs. She was diagnosed with COVID-19 pneumonia. At baseline, serum urea: 95 mg/dL, serum creatinine: 3.6 mg/dL, total leukocyte 3.8 × 103/μL, lymphocyte 1.4 × 103/μL, hemoglobin 11.7 g/L, thrombocyte: 218 × 103/μL, LDH: 271 U/L, CRP: 24.8 mg/L. Hydroxychloroquine 800 mg/day, favipiravir 2 × 1600 mg (first day), 2 × 600 mg (4 days) and moxifloxacin 400 mg/day (7 days) was given. She remained stable in terms of clinical and laboratory values during hospitalization (7 days). She was discharged after clinical improvement. It was learned that she did not come to the hospital for eculizumab treatment during COVID-19 pandemic and has not received treatment by herself for 45 days. Serum urea: 206 mg/dL, creatinine: 6.90 mg/dL, hemoglobin: 10.1 g/L, thrombocyte: 72 × 103/μL, LDH: 343 U/L. Thrombocyte values decreased to 50 × 103/μL. Single dose (1200 mg) eculizumab, and 100 mg methylprednisolone (5 days) was given. The maintenance eculizumab treatment was continued every 15 days. First month of treatment, serum creatinine: 3.73 mg/dL, hemoglobin: 11.3 g/dL, thrombocyte: 193 × 103/μL, LDH: 242 U/L. At the end of 6 months, control values were determined as serum creatinine: 3.6 mg/dL, hemoglobin: 11.2 g/L, thrombocyte: 148 × 103/μL. The laboratory tests are shown in Fig. 1. Currently, the patient is in remission, and during the follow up period treatment continues with eculizumab (1200 mg/15 days). Although the case admitted with serum creatinine 6.9 mg/ dL during the SARS-CoV-2 pandemic, it was interesting that this case achieved seamlessly both renal and hematological remission with eculizumab treatment. The COVID-19 pandemic may occur in different effects on cases with aHUS. First, recurrence of aHUS due to viral and bacterial infections is known. However, COVID-19 related aHUS relapse is extremely rare in the literature. In a case report by Ville S et al. [3], the case with aHUS relapsed with the COVID-19 infection. This case was in remission * Erhan Tatar [email protected]