Comparative Effects of Medical Versus Surgical Weight Loss on Body Composition: a Pilot Randomized Trial

Abstract

ObjectiveBariatric surgery leads to more rapid and greater weight loss (WL) compared to medical weight loss (MWL), but the differences in body composition (BC) changes for these modalities remain unclear. Due to the known health risks associated with central adiposity, we compared the changes in regional distribution of fat mass (FM) and lean mass (LM) after surgical versus MWL.MethodsIn this 1:1:1 randomized trial among 15 persons with type 2 diabetes and body mass index (BMI) 30–39.9\xa0kg/m2, we compared changes in BC, by dual-energy X-ray absorptiometry and abdominal computerized tomography, at time of 10%WL or 9\xa0months after intervention (whichever came first). Participants underwent MWL, adjustable gastric banding (AGB), or Roux-en-Y gastric bypass (RYGB). Non-parametric tests evaluated BC differences (FM, LM, and visceral adipose tissue [VAT]) within and across all three arms and between pair-wise comparisons.ResultsTwelve female participants (75% African American) completed the study. Patient age, BMI, and baseline anthropometric characteristics were similar across study arms. AGB lost more LM (MWL −\u20095.2%, AGB −\u200910.3%, p\u2009=\u20090.021) and VAT (MWL +\u200910.9%, AGB −\u200928.0%, p\u2009=\u20090.049) than MWL. RYGB tended to lose more VAT (MWL +10.9%, RYGB −\u200920.2%, p\u2009=\u20090.077) than MWL. AGB tended to lose more LM than RYGB (AGB −\u200912.38%, RYGB −\u20097.29%, p\u2009=\u20090.15).ConclusionsAt similar WL, AGB lost more LM and VAT than MWL; RYGB similarly lost more VAT. Given the metabolic benefits of reducing VAT and retaining LM, larger studies should confirm the changes in BC after surgical versus medical WL.Clinical Trial RegistrationNCTDK089557 – ClinicalTrials.gov