Synthesis and exploration of anticancer activity of silver nanoparticles using Pandanus amaryllifolius Roxb. leaf extract: Promising approach against lung cancer and breast cancer cell lines

Abstract

The development of scalable, biocompatible, cost effective, and simple techniques for silver nanoparticles (AgNPs) synthesis is one of the significant fields in Nanoscience research. Hence, in this study, the green chemicals present in the Pandanus amaryllifolius Roxb. leaves were extracted by using the Soxhlet extraction apparatus. Pandanus amaryllifolius Roxb. leaves extract composed of Catechin, Gallic acid, Indole, Benzyl acetate, and Cresol, which can be used in the reduction of silver ions (Ag+) into nano silver (Ag0). The preliminary preparation of AgNPs was observed by color change to brown and it is further characterized by UV-Vis, FT-IR, SEM, XRD, TGA and DTA studies. The cytotoxicity activity of Pandanus amaryllifolius Roxb. leaves-silver nanoparticles (PARLE-AgNPs) was tested on cancer cell lines. Interestingly, the synthesized PARLE-AgNPs exhibited robust anticancer activity against both lung cancer (A549) and breast cancer (MCF7) cell line and results are compared with standard cisplatin drug. The IC 50 of cell inhibition of PARLE-AgNPs against MCF-7 & A549 cell lines was found to be 27.19\xa0µg/ml and 22.36\xa0µg/ml respectively. Quantum chemical studies confirm the electron donation property of Pandanus amaryllifolius Roxb. leaves extract. This greenly prepared silver nano-formulation has a huge potential to be explored in various diverse aspects.