Meta-Analysis of Regorafenib-Associated Adverse Events and Their Management in Colorectal and Gastrointestinal Stromal Cancers

Abstract

IntroductionTo assess the risk factors associated with regorafenib-related adverse events (AEs) in metastatic colorectal cancer (mCRC) and gastrointestinal stromal tumors (GIST). We also evaluated different measures of combatting AEs and their success rate to aid physicians in early identification and management of reported AEs.MethodsA literature search was conducted through the electronic databases PubMed, Embase, and Cochrane Central Register of Controlled Trials up to May 2018 according to the pre-specified inclusion and exclusion criteria. Pooled estimates with Pearson correlation were obtained with fixed or random-effects models.ResultsFrom our analysis, it was evident that AEs were more common in patients aged less than 65\xa0years compared to those aged at least 65\xa0years (71.3% vs. 27.6%, p\u2009=\u20090.001). A statistically significant correlation was observed between the occurrence of AEs and a dose of 160\xa0mg (r\u2009=\u20090.967; p\u2009=\u20090.001) while no significant correlation was found at 120\xa0mg and 80\xa0mg. The common measures used to manage AEs included lowering the regorafenib dose (41%), intermittent drug withdrawal (66.7%), and complete drug withdrawal (19%). About 57% of patients recovered from AE after their initiating dose was lowered.ConclusionRegorafenib-associated AEs are more common at an initiating dose of 160\xa0mg. Considering that the efficacy depends on the dosage, 120\xa0mg might be a better choice for mCRC and GIST patients; further studies are needed to validate the results of our analysis. Further prompt identification and management of AEs are required to help the patients continue with drug therapy.