Randomized controlled trial comparing the efficacy of pectoral nerve block with general anesthesia alone in patients undergoing unilateral mastectomy

Abstract

This study was conducted to evaluate the efficacy of pectoral nerve block for post-operative analgesia in breast surgery patients. This double blinded, randomized controlled trial was conducted after Clinical Trials Registry-India registration. Sixty ASA grade I–II female patients undergoing unilateral modified radical mastectomy under general anesthesia, were recruited pre-operatively in two groups. PECS group ( n \xa0\u2009=\xa0\u200929) was given ipsilateral pectoral nerve block I & II while the CONTROL group ( n \xa0\u2009=\xa0\u200929) directly proceeded to surgery. Our primary outcome was comparison of immediate post-operative pain scores at rest and movement. The secondary outcomes were post-operative pain scores at 2, 4, 6, 12, 18, and 24\xa0h, total intraoperative fentanyl consumption, time to rescue analgesia, post-operative nausea vomiting, and complications, if any. Categorical data was analyzed by using the chi-squared test or Fishers Exact test. Comparison of pain scores was analyzed by using the Independent sample t test. The immediate post-operative pain scores in two groups were comparable. The pain scores were also comparable at 4, 6, 12, and 24\xa0h; but statistically significantly lower in PECS group at 2 and 18\xa0h. The total intraoperative fentanyl consumption was also reduced in PECS group ( P \xa0=\xa00.009). Only 9 patients in PECS group (796.5\xa0min) as compared to 22 patients in CONTROL group (387.7\xa0min) required rescue analgesia ( P\u2009 \xa0=\u2009\xa00.001). Pectoral nerve block benefits patients undergoing mastectomy by achieving similar post-operative pain scores with decreased consumption of intraoperative and post-operative opioids. Registration. Clinical Trials Registry of India, (CTRI/2017/04/008289). ctri.nic.in