Omeprazole

Abstract

Subacute cutaneous lupus erythematosus: case report A 67-year-old woman developed subacute cutaneous lupus erythematous (SCLE) during treatment with omeprazole. The woman presented with waxing and waning facial eruption which were present for several years. It was reported that she had been receiving omeprazole daily [dose and route not stated] for years; however, denied association with her cutaneous eruption. Physical examination showed erythematous atrophic plaques and thin plaques along with scales on the bilateral cheeks within a diffuse background of telangiectasia. Laboratory investigations revealed decreased levels of complement factor 3 (C3), complement factor 4 (C4), and a absence of antinuclear antibodies and anti-dsDNA antibodies. A punch biopsy demonstrated cell-poor interface dermatitis with scattered apoptotic keratinocytes, along with superficial perivascular and perifollicular lymphoplasmacytic infiltrate. Based on these findings and clinical presentation, a diagnosis of SCLE possibly associated with omeprazole was made [duration of treatment to reaction onset not stated]. The woman’s treatment with omeprazole was discontinued, and she was treated with unspecified antimalarials [outcome not stated].