Dapsone

Abstract

Drug hypersensitivity syndrome : case report A 49-year-old woman developed drug hypersensitivity syndrome during treatment with dapsone for Sneddon-wilkinson disease (SWD). The woman had recurrent pustules and papules on the flexural areas of the trunk and extremities for 3 years. She was initially treated with unspecified antifungal therapy considering candidal intertrigo. However, her pustules recurred subsequently. Therefore, she was investigated. Based on the findings, she was diagnose with SWD. Subsequently, she started receiving dapsone [dosage and route not stated]. However, after 2 weeks of dapsone initiation, she developed erythematous desquamating plaques on trunks and extremities. Despite having the cutaneous lesion, she did not have fever, jaundice, lymphadenopathy and abdominal tenderness. Laboratory investigation for CBC and liver function tests were all normal. Hence, a diagnosis of dapsone hypersensitivity syndrome was considered. Consequently, the woman’s dapsone was switched to colchicine. Following 6 weeks of colchicine initiation, lesions did not recur. Thereafter, she was in remission for 6 months.