Lamotrigine

Abstract

Stevens-Johnson syndrome: case report A 19-year-old woman developed Stevens-Johnson syndrome (SJS) during treatment with lamotrigine for epileptic seizure. The woman, who had an epileptic seizure, started receiving treatment with lamotrigine [dosage and route not stated]. Three weeks later, she presented with suspected SJS secondary to the use of lamotrigine. On presentation skin biopsy confirmed SJS. Mucosal injury was associated with hyperalgesic stomatitis and conjunctivitis. Ten days later, her mouth opening was limited, and she presented with bilateral adhesions between the upper and lower lips of 6mm on the left and 3mm on the right resulting in aesthetic and functional damage. These synechiae were not painful but resulted in obvious functional damage. No genital or ocular synechiae was observed. The woman was advised for lip movements with maximum mouth opening several times a day until full healing. She denied to undergo a surgical procedures for labial synechiae. She was then proposed for genital and ocular monitoring [outcome not stated].