Reactions Weekly | 2021
Multiple drugs
Abstract
Hypersensitivity: 9 case reports In a retrospective study consisting of 120 patients, who underwent beta-lactam (BL) drug provocation test (DPT) for suspected BL hypersensitivity reaction from August 2016 to December 2017, nine patients (five boys and four girls) aged 1-11 years were described [not all ages stated], who developed delayed hypersensitivity reaction, immediate hypersensitivity reaction, drug hypersensitivity reaction or anaphylaxis following treatment with amoxicillin, amoxicillin/clavulanic acid, cefepime or ibuprofen [dosages not stated; not all indications and routes stated; time to reaction onsets not clearly stated]. The patients were receiving amoxicillin (n=2), amoxicillin/clavulanic acid [amoxicillin-clavulanate] (n=5), IV cefepime (n=1) and ibuprofen (n=1) as antibiotic therapy or for central line infection. Subsequently, the patients developed delayed hypersensitivity reaction (n=3), immediate hypersensitivity reaction (n=3), drug hypersensitivity reaction (n=2) and drug hypersensitivity reaction in the form of anaphylaxis (n=1). Beta lactams and ibuprofen was suspected to have caused these hypersensitivity reactions. Therefore, the patients discontinued their respective therapy with beta-lactams and ibuprofen. Thereafter, hypersensitivity reaction resolved in all nine patients. Subsequently, out of nine patients, eight patients underwent an oral drug provocation test with suspected drugs leading to positive result. One remaining patient underwent intradermal test with positive findings. Therefore, drug-induced hypersensitivity was confirmed in all nine patients [final outcomes not stated].