Cisplatin/etoposide

Abstract

Pneumonia: case report An approximately 67-year-old man developed pneumonia during treatment with cisplatin and etoposide for lung cancer metastases to lymph nodes. The man, who had an occlusive ventilation disorder, presented with a tumour in the hilum of his right lung at 66 years of age. Further analyses revealed that the tumour in the right middle lobe invaded the middle lobe vein and left atrium; however, a pathological diagnosis could not be made. Right lung cancer (cT4N0M0; stage IIIA) was suspected. Surgery was performed, with preservation of the lung function. The pathological diagnosis was large cell neuroendocrine carcinoma (pT4N0M0 stage IIIA). Notably, the tumour invaded his left atrium myocardium. He experienced a minor complication in the form of a drug allergy [drug not specified], which improved after the offending agent was discontinued. He was discharged 20 days post surgery. Thereafter, he underwent three courses of adjuvant chemotherapy with cisplatin [CDDP] and irinotecan [CPT-11]; however, he experienced mediastinal lymph node recurrence 1 year after the surgery (at approximately 67 years of age). Therefore, the lymph node was resected; lung cancer metastasis was identified in only one of the resected lymph nodes. Thereafter, he received two courses of chemotherapy with cisplatin and etoposide [VP-16; routes and dosages not stated]. However, he subsequently developed druginduced pneumonia secondary to cisplatin and etoposide. At the time of this report, he remained alive, without cancer treatment and without recurrence at 58 months post surgery [reaction outcome not stated].