Synchronous Primary Cancer of Cervix and Non-genital Metastatic Tumor of Ovary: A Rare Case Report

Abstract

Synchronous malignancies in the female genital tract are uncommon. We here present the first documented case of a synchronous cervical adenocarcinoma with a non-cervical metastatic ovarian tumor. A 41-year-old woman was admitted with complains of abdominal pain on and off. General physical examination and systemic examination were normal. CT suggested a possibility of complex cystic adnexal masses likely an ovarian tumor. The uterus and cervix appeared unremarkable. A radical abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Based on the histopathological and immunohistochemical findings, a diagnosis of a synchronous metastatic tumor to the ovary (most likely gastrointestinal origin) and primary adenocervical carcinoma was made. Multiple genital malignancies often present as a diagnostic dilemma. It is essential to differentiate primary malignancies from metastatic disease as there is great variation in overall survival and management. Immunohistochemistry plays a key role when the histomorphological features fail to decipher the origin of malignancy.