siRNA and Ovarian Cancer

Abstract

RNA interference (RNAi) is an emerging field of genetic intervention of the new millennium for incurable disease conditions where conventional treatment fails. MicroRNA (miRNA) and small interfering RNA (siRNA) are two components of such RNAi. Exogenous double-stranded siRNA targets specific mRNA and prevents anomalous gene expression producing such disease conditions. Ovarian cancer is such a disease which can hardly be treated by conventional therapy due to recurrence and drug resistance. Hence, siRNA\xa0may pose an attractive alternative to deal with recurrent and refractory ovarian cancer because of its simple straightforward mechanism of knocking down faulty genes responsible for its dismal prognosis. With success already at hand in rare genetic disease it seems worthwhile that\xa0development so far of such therapy in ovarian cancer is critically analysed, hence this review.