Randomized Single-Case Intervention Designs and Analyses for Health Sciences Researchers: A Versatile Clinical Trials Companion

Abstract

Aim An expository note introduces health sciences researchers to randomized single-case intervention designs, an adaptation of interrupted time-series methodology, and the staple of a scientifically credible small-sample research paradigm. Methods Detailed examples illustrating two different randomized single-case procedures are presented to highlight the techniques’ advantages relative to small-sample nonparametric procedures that are commonly applied in the medical and health sciences fields. Results Numerous positive outcomes, based on both statistical simulation studies and actual intervention research investigations, support the applicability and value of these procedures. Conclusion Randomized single-case intervention designs are recommended for consideration by health sciences researchers.