Archive | 2019
Pathology of pediatric oligodendroglioma
Abstract
Abstract Oligodendroglial tumors represent approximately 6% of infiltrative gliomas in adults and 1 This group of tumors includes oligodendroglioma (WHO grade II) and anaplastic oligodendroglioma (WHO grade III). The diagnosis of oligodendroglioma portends a good prognosis as compared to other gliomas in both patient populations; however, the pediatric population shows longer overall survival than their adult counterparts, particularly following complete surgical resection. 2 The most common clinical signs and symptoms include seizure and headache in both adults and children, which also show similar imaging findings. 2 , 3 , 4 In adults, the diagnosis of oligodendroglioma is based on specific histopathological and molecular features (IDH1 mutation and 1p/19q co-deletion). Although the histological features are similar in the pediatric population, the common molecular features noted in adult tumors are absent, making a definitive diagnosis challenging. 5