Archive | 2021
Recent advances in multicomponent microwave-assisted Ugi reactions
Abstract
Abstract The use of microwave (MW) energy in organic synthesis has become a norm in research settings. The microwave-assisted organic synthesis (MAOS) allows for short reaction times and increased reaction yields. Multicomponent (MC) reactions have also become equally popular because of easy accessibility of diverse libraries of compounds, high efficiency, and atom economy. The multicomponent Ugi reaction generally consists of an isocyanide, an aldehyde or ketone, an amine, and a carboxylic acid as the starting materials to generate α-acyl-amido amides. In particular the microwave-assisted Ugi reaction provides one of the best reaction models to obtain biologically active scaffolds in short time. The reaction can be set up as a three-component coupling (3CC), four-component coupling (4CC), or five-component coupling (5CC) reactions. After the Ugi adduct is formed, many post-Ugi reactions have also been studied. This chapter focuses on the recent advances reported in the last 5 years regarding the multicomponent microwave-assisted Ugi reaction.