Phytomedicines: Synergistic and antagonistic phytometabolites-drug interactions

Abstract

Abstract Phytometabolites-drug interactions, when administered concurrently, may affect the body s ability to metabolize the medication or provoke critical side repercussions. Clinically considerable medicament interactions present a potential danger to the sick person and may lead to alterations in pharmaceutical, pharmacokinetic, or pharmacodynamic features. Nourishment and way of living can occasionally have a considerable effect on medication. This chapter is structured in two parts, based on a study of the production mode as well as the factors favoring the production of phytometabolite-drug interactions, comprising: general aspects regarding the production of phytometabolite-drug interactions, the changes produced by medication, aspire to nutritional status, the effect of phytometabolites and their compounds in drug metabolism, and the interaction of grapefruit juice with certain classes of drugs to avoid accidents caused by active medications in an inappropriate dietary context, and the part that includes the mechanism of producing the interaction between grapefruit juice and diclofenac (DCF) based on the pharmacokinetic parameters determined experimentally.