Deep multiphysics: Coupling discrete multiphysics with machine learning to attain self-learning in-silico models replicating human physiology

Abstract

OBJECTIVES\nThe objective of this study is to devise a modelling strategy for attaining in-silico models replicating human physiology and, in particular, the activity of the autonomic nervous system.\n\n\nMETHOD\nDiscrete Multiphysics (a multiphysics modelling technique) and Reinforcement Learning (a Machine Learning algorithm) are combined to achieve an in-silico model with the ability of self-learning and replicating feedback loops occurring in human physiology. Computational particles, used in Discrete Multiphysics to model biological systems, are associated to (computational) neurons: Reinforcement Learning trains these neurons to behave like they would in real biological systems.\n\n\nRESULTS\nAs benchmark/validation, we use the case of peristalsis in the oesophagus. Results show that the in-silico model effectively learns by itself how to propel the bolus in the oesophagus.\n\n\nCONCLUSIONS\nThe combination of first principles modelling (e.g. multiphysics) and machine learning (e.g. Reinforcement Learning) represents a new powerful tool for in-silico modelling of human physiology. Biological feedback loops occurring, for instance, in peristaltic or metachronal motion, which until now could not be accounted for in in-silico models, can be tackled by the proposed technique.