Prospective observational study on the clinical behavior of dental implants in patients with hemophilia. Preliminary results

Abstract

Abstract Introduction Hemophilia is a recessive congenital hereditary hemorrhagic disorder characterized by the decrease in or absence of the functional activity of factor VIII (Hemophilia A) or factor IX (Hemophilia B). The hematological medical treatment for these patients is systemic replacement therapy with factor VIII or factor IX concentrates. Dental implants are considered the gold standard for the replacement of missing teeth. There is no evidence or safe protocol for their use in patients with hemophilia. The objective of this study was to evaluate the clinical osseointegration and the incidence of postoperative bleeding in patients with hemophilia. Materials and methods The patients included in this study were over 18 years old with a diagnosis of Hemophilia. A surgical implant protocol was implemented, supported by systemic and local hemostatic measures. Age, type of hemophilia, pre- and post-factor levels, gingival index, surgical duration, edema and pain were recorded for each case. In the event of hemorrhage, the bleeding index was determined. At 4 months, the success of the implant was evaluated using the absence of pain, suppuration and clinical mobility as parameters. Results 15 surgeries were performed and 21 implants were placed in 10 patients. All the implants were successful in terms of the evaluated parameters. Among the 15 surgeries performed, bleeding was detected in 3. Conclusion The preliminary results found in this study seem to establish that the proposed surgical implant and hemostatic protocol is a predictable treatment for the placement of dental implants in patients with hemophilia.