Dense CO2 technology: Overview of recent applications for drug processing/formulation/delivery

Abstract

Abstract Dense carbon dioxide technology is promising for the processing of drug compounds and development of varied pharmaceutical formulations through micronization, coprecipitation, encapsulation and coating techniques. The main advantages of this technology are the possibility to process thermo-sensitive compounds at low temperatures and using no/low amounts of organic solvents. Many processes have been developed and modified throughout the years to allow the production of composite materials with the desired characteristics. In this review, various processing methods using dense CO2 and recent process modifications are classified, and their differences and similarities are discussed. Formulation strategies to improve dissolution and flow properties of active compounds are also presented, giving insights into the selection of the most suitable formulation strategy and processing method.