Hematologic disorders during essential hypertension.

Abstract

BACKGROUND\nBesides the traditional risk factors, hematological changes may be involved in the development of arterial hypertension and in its pathogenesis.\n\n\nMETHODS\nThe study, conducted on a sample of 545 subjects, 215 with hypertension and 330 witnesses, were evaluated for peripheral blood parameters in western Algeria; Logistic regression analysis was used to predict hypertension with hematological parameters.\n\n\nRESULTS\nThe characters studied related significantly; lower red blood cell levels have a three-and-a-half-fold risk of developing hypertension compared to those who have normal red blood cell counts (OR\u202f=\u202f3.64, 95% CI\u202f=\u202f1.37-9.65, p\u202f<\u202f0.05). Subjects who have mean corpuscular volume rate below 80\u202ffl are more exposed to hypertension (OR\u202f=\u202f13.58, 95% CI\u202f=\u202f4.68-39.41, p\u202f=\u202f0.000). The mean corpuscular hemoglobin concentration reveals that subjects who have a lower than normal (<27\u202fpg) are once less exposed to hypertension (OR\u202f=\u202f0.04, 95% CI\u202f=\u202f0.01-0.13, p\u202f=\u202f0.000). Subjects who have lower platelet count than normal are twelve times more exposed to hypertension (OR\u202f=\u202f12.13, 95% CI\u202f=\u202f1.45-101.18, P\u202f=\u202f0.021). Finally, the increase in sedimentation rate at one hour increases the risk of hypertension by 56.63 times compared to subjects with normal sedimentation rate (OR\u202f=\u202f56.63, 95% CI\u202f=\u202f3.37-597.33, P\u202f=\u202f0.001).\n\n\nCONCLUSIONS\nHematological profile associated with essential hypertension retained Red blood cells ratio, mean corpuscular volume, mean corpuscular hemoglobin concentration, platelet ratio, and sedimentation rate at one hour.