A robust camphor-based colorimetric and fluormetric dual-modal probe with a large Stokes shift for real-time monitoring of endogenous labile Fe2+ in vivo and in vitro

Abstract

Abstract Fe2+ plays a critical role in many physiological processes in the human body. The abnormal level of Fe2+ is implicated in a variety of diseases ranging from anemia to heart failure and even cancer. Herein, a new camphor-derived colorimetric and fluormetric dual-modal probe CCO was constructed for real-time monitoring and imaging of Fe2+ in vitro and vivo. The probe CCO manifested excellent selectivity, superior sensitivity (LOD\xa0=\xa08.3\xa0nM), large Stokes shift (~208\xa0nm), rapid reaction time (