The effect of green coffee extract supplementation on serum oxidized LDL cholesterol and total antioxidant capacity in patients with dyslipidemia: A randomized, double-blind, placebo-controlled trial

Abstract

Abstract Introduction Previous studies on laboratory animals have evaluated the effects of CGA (chlorogenic acids) rather than GCBE (green coffee bean extract), and few studies have been conducted on human models. Thus, the purpose of the present study was to assess the effect of GCBE consumption on serum oxidized LDL-cholesterol (OX-LDL) and total antioxidant capacity (TAC) on patients with dyslipidemia. Method In this randomized, placebo-controlled, clinical trial, 70 male participants (age range 30–55 years) were assigned from the outpatient clinic of Arvand Petrochemical Company in Mah-shahr, Ahwaz, Iran to use 800\u2009mg/day GCBE supplements or placebo for 8 weeks. Serum TAC and OX-LDL were determined by enzyme-linked immunosorbent assay. Results Compared with the placebo, GCBE intake led to a significant reduction in OX-LDL (−31.18\u2009ng/ml) (P-value\u2009=\u2009 Conclusions The current trial showed that the intake of 800\u2009mg per day of GCBE may have favorable effects on TAC, and OX-LDL in patients with dyslipidemia. However, further studies are required to confirm the veracity of these results.