Guideline on myeloproliferative neoplasms: Associacão Brasileira de Hematologia, Hemoterapia e Terapia Cellular

Abstract

s obtained with the search strategy in the consulted information bases performed in an independent and blinded manner, strictly adhering to the inclusion and exclusion criteria, separating the works with potential relevance. Articles were required to display enlightening titles and abstracts and received an in-depth scrutiny. Only full-text papers were eligible for critical evaluation. Application of results – external validity The level of Scientific Evidence follows the type of study according to Oxford (Table AI.1).20 – Table AI.4 Spreadsheet used to describe and explain the results of each study. Evidence included Study design Selected population Follow-up time Considered outcomes Expression of results: percentage, risk, odds, hazard ratio, mean The selected evidence comprise a randomized controlled clinical trial (RCT) submitted to an appropriate critical evaluation checklist (Table AI.2). The critical evaluation of the RCT allows classification according to the JADAD score,21 considering the JADAD tests <three (3) as inconsistent (grade B), and those with a score ≥three (3), consistent (grade A). When the selected evidence was defined as a comparative study (observational cohorts or non-randomized clinical trial), it was submitted to an appropriate critical evaluation checklist (Table AI.3), allowing the classification of the study according to the NEW CASTLE-OTTAWA SCALE,22 considering cohort studies consistent with score ≥6 and inconsistent