Transcatheter Edge-to-Edge Repair for Primary (Degenerative) Mitral Regurgitation: Registries and Trials.

Abstract

The MitraClip is the only approved transcatheter edge-to-edge repair device that is commercially available for the treatment of severe, symptomatic, primary (degenerative) mitral regurgitation in patients deemed to be at prohibitive risk by a heart team. Transcatheter edge-to-edge repair can be safely performed with a low rate of periprocedural adverse events despite a predominantly elderly patient population with multiple comorbidities. Transcatheter edge-to-edge repair is associated with improvement in mitral regurgitation severity; left ventricular dimensions and remodeling; heart failure rehospitalizations; and, in high-risk groups, an improvement in survival compared with medical therapy.