Medium- and long-chain triglycerides attenuate lipid accumulation and regulate the expression of proteins related to lipid metabolism in oleic acid-induced lipid deposition in human hepatic LO2 cells

Abstract

Abstract This research investigated the effects of different triglycerides on lipid deposition and the underlying mechanism in oleic acid-induced human hepatic LO2 cells. Cells were treated with vehicle, oleic acid (OA), OA\u202f+\u202fcoconut oil (CO), OA\u202f+\u202frapeseed oil (RO), OA\u202f+\u202fphysical mixture oil of CO and RO (CROM), OA\u202f+\u202finteresterified oil of CO and RO (CROI, rich in medium- and long-chain triglycerides (MLCTs)), OA\u202f+\u202f1,3-di-oleic-2-medium chain triglycerides (OMO, a kind of MLCTs) and OA\u202f+\u202f1,3-di-oleic-2-palmitic triglyceride (OPO) for 24\u202fh. Compared with the OA group, OA\u202f+\u202fCROI and OA\u202f+\u202fOMO treatment significantly reduced (P