Solid dispersion melt crystallization (SDMC) concept using binary eutectic system for improvement of dissolution rate

Abstract

Abstract From the designs of product and industrial process perspectives, the solubility of a target material is one of the most valuable qualities. We proposed the ‘solid dispersion melt crystallization (SDMC) concept’ as a original strategy for dispersing a target material in a matrix one, in which the target material is naturally dispersed between the crevices formed by the matrix material precipitated first. Furthermore, the effects of introducing some operations, such as cooling, agitation and aeration, to the SDMC concept on the dissolution rate were investigated by a binary eutectic system. According to the experimental results, the dissolution rate was enhanced by the operations (cooling, agitation and aeration). This improvement in the dissolution rate was attributed to the SDMC concept-based enhancement of the nucleation rate. Therefore, it was revealed that an increase in the nucleation rate due to the SDMC concept had effectively improved the dissolution rate.