Half sandwich platinum group metal complexes of thiourea derivative ligands with benzothiazole moiety possessing anti-bacterial activity and colorimetric sensing: Synthesis and characterisation

Abstract

Abstract Complexes 1–9 were prepared by the reaction of [(arene)MCl2]2 (arene\u202f=\u202fp-cymene, Cp*; M\xa0=\xa0Ru, Rh and Ir) with thiourea derivative ligands L1, L2 and L3. These complexes have been isolated as cationic bidentate (N, S), neutral bidentate (N, S) as well as neutral mono-dentate (S) complexes. Anti-bacterial activity studies were carried out for these complexes as well as the ligands against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli; Klebsiella pneumoniae) in which all the complexes (except complexes 2 and 6) as well as the ligands (except L3) showed anti-bacterial activity. In addition to the biological studies, colorimetric sensing study using silver nanoparticles was also carried out where, ligands L1 and L3 showed agglomeration effects.