Materials Today: Proceedings | 2021
Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride
Abstract
Abstract 2-Amino-5-mercapto-1,3,4-thiadiazole (M1) was prepared by the cyclization of thiosemicarbazide with carbon disulfide and anhydrous sodium carbonate in ethanol. The compound (M1) was used as precursor to react with different aromatic aldehydes to yield hydrazones (M2-M4). Thereafter, hydrazones (M2-M4) is reacted with chloro acetyl chloride to obtain 5-(sub. benzylidene) amino]-2-thioacetyl chloride-1,3,4-thiadiazole compounds (M5–M7). The compounds (M8–M10) and (M11–M13) were synthesized by the reaction of compounds (M5–M7) with benzotriazole or Indole, respectively. All the synthesized compounds were identified according to their physical properties, spectroscopic data (FT-IR). At the same time, some of these prepared compounds were identified by the use of 1H NMR spectroscopy. In addition to the systematic identification of some active functional groups in these compounds. Biological activity for some of the synthesized compounds was evaluated against two types of bacterial and two types of fungal.