Association of VEGF polymorphisms and breast cancer susceptibility: Systemic review and meta-analysis

Abstract

Abstract Aim This meta-analysis aimed to evaluate the association between different VEGF gene polymorphisms (VEGF 2578 C/A, VEGF 936 C/T, VEGF 634\xa0G/C, VEGF 460\xa0T/C and VEGF 405 C/G). Methodology Meta-analysis was performed by collecting the results of 24 appropriate studies that were retrieved from PubMed central, Embase and Google Scholar. The statistical analyses were performed by using Review Manager 5.4 software. Results The Meta analysis results revealed that there is no significant association between VEGF 2578 C/A, VEGF 460\xa0T/C, VEGF 634\xa0G/C, and 405\xa0G/C gene polymorphisms with the risk of breast cancer. Additionally, a significant association was identified in VEGF 936 C/T polymorphism with risk of breast cancer. No publication bias was observed. Conclusion The results revealed that VEGF 2578 C/A, VEGF 460\xa0T/C, VEGF 634\xa0G/C, 405\xa0G/C gene polymorphisms were not associated with the risk of breast cancer whereas VEGF 936 C/T polymorphism maybe associated with breast cancer. Further well deliberated studies with bigger sample size are essential to evaluate the associations.