Effect of selenium supplementation on lipid profile levels: An updated systematic review and meta-analysis of randomized controlled clinical trials

Abstract

Abstract Aims The aims of this meta-analysis were to assess the effects of selenium supplementation on lipid profile levels in clinical trial studies. Methods A systematic search of literature was carried out in PubMed, Scopus, ISI web of science, Ovid and Cochrane library up to January 19, 2019. Of 2318 relevant articles identified at the first step of search, 19 trials with 31, 21, 29 and 22 effect sizes were used for the meta-analysis assessing the effects of selenium supplementation on blood levels of HDL-C, LDL-C, TC and TG, respectively. Results Results of the random effect model meta-analysis showed significant effect of selenium supplementation on serum level of TC (WMD: 2.02\u202fmg/dl; 95% CI\u202f=\u202f−3.86, −0.17; P\u202f=\u202f0.032) while it had no significant effects on serum levels of HDL-C (WMD: 0.37\u202fmg/dl; 95% CI\u202f=\u202f−0.66, 1.34; P\u202f=\u202f0.45), TG (WMD: 2.43\u202fmg/dl; 95% CI\u202f=\u202f−6.27, 1.40; P\u202f=\u202f0.21), and LDL-C (WMD: 0.32\u202fmg/dl; 95% CI\u202f=\u202f−2.42, 3.06; P\u202f=\u202f0.82). Results of subgroup analysis showed that when the dosage of selenium supplementation was 200\u202fμg/day or when the baseline level of serum TC was >200\u202fμg/dl, selenium supplementation could decrease significantly TG and TC concentrations, respectively. Conclusion Results of the current meta-analysis study showed that selenium supplementation could decrease significantly serum levels of TC and TG while it had no beneficial effects on other lipid profile levels in clinical trial studies.