New acetylenic compounds and lignans from Dolomiaea berardioidea (Franch.) Shih

Abstract

Abstract Two new acetylenic compounds (1 and 2), two new lignans (3 and 4) along with eight known lignans (5−12), ten known terpenoids (13−22) and one known aromatic compound (23) were isolated from the whole plants of Dolomiaea berardioidea (Franch.) Shih. Structures of new compounds were elucidated by combined use of HRESIMS, 1D and 2D NMR and CD spectroscopic methods. The absolute structures of 1 and 3 were further confirmed by Cu Kα X-ray crystallographic analyses. In addition, all isolated compounds were also tested for their inhibitory effects against LPS-induced NO production of RAW 264.7 macrophage. Compound 22 displayed potential anti-inflammatory activity with IC50 value of 7.4\u2009μM.