The role of 18F-FDG PET/CT metabolic parameters in pediatric lymphoblastic lymphoma

Abstract

Abstract Objective This retrospective study aimed to evaluate the role of metabolic parameters of 18F-FDG PET/CT in pediatric lymphoblastic lymphoma (LBL). Methods Thirty patients with LBL underwent 42 scans. Metabolic parameters including maximum standardized uptake value (SUVmax), total metabolic tumor volume (TMTV), and total lesion glycolysis (TLG) were measured at baseline PET/CT. Univariate and multivariate analysis for survival were performed to assess their prognostic value. Twelve patients underwent PET/CT after reinduction regime, and the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET/CT for predicting relapse were calculated. Results Patients with stage Ⅳ had a higher TMTV than those with stage III (p\u202f=\u202f0.031). Besides, patients with T-LBL or mediastinal involvement had a high TMTV and TLG (p\u202f \u202f0.05). Children with a low TMTV ( Conclusions Metabolic parameters of baseline PET/CT were not predictive of outcomes in children with LBL. PET/CT done after the reinduction regime had better sensitivity and NPV than CT alone, and a negative scan could be a reliable indicator for sustained remission.