Morphological study on the pore growth profile of poly(ε-caprolactone) bi-modal porous foams using a modified supercritical CO2 foaming process

Abstract

Abstract Bi-modal porous material is considered to have superior physical and tissue-inducing properties. This study reports on the fabrication of bi-modal porous poly(e-caprolactone) (PCL) scaffolds using two-step depressurization supercritical CO2 foaming process. In a single process, large pores over 100\u2009μm nucleated in the slow depressurization step, and coalesced during holding stage; small pores below 40\u2009μm were formed in the rapid depressurization step. Investigation on foaming parameters demonstrated that soaking time longer than 0.5\u2009h was necessary to produce bi-modal pores. It was noted that the holding stage had a significant impact on the final pores. In particular, intermediate pressure would affect the plasticizing capabilities of CO2 to increase (5–7\u2009MPa) or decrease (7–12\u2009MPa) pore size. In all, bi-modal porous PCL foams with around 80% porosity were produced, and this work provided a potential reference to efficient design of bone tissue engineering scaffolds.