Diastereoselective Catalyst-Free Construction of Isoxazolidine-cis-fused Phospha dihydrocoumarins via an Intramolecular Nitrone–Vinylphosphonate Dipolar Cycloaddition

Abstract

Abstract An efficient stereoselective method towards the construction of isoxazolidine- cis -fused phosphadihydrocoumarins frameworks involving an intermolecular 1,3-dipolar nitrone cycloaddition reaction utilizing O- vinylphosphonylated salicylaldehydes and N -substituted hydroxylamines in situ formation of Nitrone–Vinylphosphonate bifunctional intermediates under catalyst free condition have been described.