Acne: Disorder of luteal androgen management

Abstract

Abstract According to the theory of Endobiogeny, acne is an endocrine disorder of luteal hormone excess at the level of the skin, resulting in excess sebum production, narrowing or plugging of hair follicles, and dysbiotic growth of commensal and noncommensal flora. Acne can be structuro-functional or functional. Structuro-function refers to how the organism adapts to specific structural needs, such as the neonatal period, adolescences, and genital recycling in adulthood. Functional acne is in response to adaptation demands, such as stress or disruptions in chronobiologic rhythms. The acne terrain represents dysfunction in all four endocrine axes and emunctories related to lipid-protein metabolism and detoxification. Acne, while superficial, may reflect systemic imbalances or risks of future disorders and should be investigated and treated systemically. A symptomatic suppression of topical mechanisms of disease may offer short-term results, but do not address the underlying imbalances found in the acne terrain.