Acute subjective sensory perceptions predict relative reinforcing effects of smoked nicotine.

Abstract

INTRODUCTION\nSmoking is believed partially reinforcing via immediate sensory perceptions. Yet, unknown is whether a cigarette s relative reinforcing efficacy can be predicted by these perceptions and whether this relationship may vary due to constituents known to alter those perceptions.\n\n\nMETHODS\nSensory perceptions of acute smoking were examined as predictors of subsequent cigarette choice behavior. Also tested was whether nicotine content or menthol affected this relationship. Adult dependent smokers (N\xa0=\xa037) participated in five sessions comparing cigarettes varying in nicotine contents (NIC; 1.3, 2.3, 5.5, 11.2, and 17.4\xa0mg/g), relative to the very lowest nicotine content, 0.4\xa0mg/g (VLNC). Non-menthol (n\xa0=\xa017) and menthol (n\xa0=\xa020) cigarettes-matched on nicotine-were provided based on participant preference. One NIC was compared versus VLNC per session (single-blinded); NIC content order was randomized across sessions on separate days. Perceptions (e.g., liking , satisfying ) were measured immediately after initial sampling of NIC or VLNC, followed by a validated puff-by-puff choice procedure to determine preference for each NIC versus VLNC.\n\n\nRESULTS\nNIC perceptions (difference from VLNC) and puff choices increased with nicotine. Menthol moderated associations between perceptions and nicotine; and between puff choices and nicotine. Perceptions were predictive of puff choice-greater magnitude of difference in perceptions between VLNC and NIC led to more NIC puff choices. When testing perceptions prediction of puff choices, neither the main effect of menthol or interaction of Perceptions\xa0X\xa0Nicotine Condition were significant.\n\n\nCONCLUSIONS\nConsistent with assumed-but rarely tested-causes of smoking reinforcement, sensory perceptions from a cigarette predict its relative reinforcing efficacy.