Advances in Integrative Medicine | 2021
Clinical efficacy of a buccoadhesive paste from fenugreek seeds (Trigonella foenum graecum L.) on recurrent aphthous stomatitis in non-toxic concentration
Abstract
Abstract Context Recurrent aphthous stomatitis (RAS) is a highly prevalent oral lesion that is limited in many cases to symptomatic remedies. Objective In this work, a buccoadhesive paste was prepared from fenugreek extract and clinically evaluated on RAS patients. Design This study was a double blind randomized clinical trial. Setting The study took place at Kerman University of Medical Sciences, Department of Oral Medicine, School of Dentistry. Participants Sixty patients randomly in two groups were treated with fenugreek buccoadhesive paste (FBP) and dexamethasone mouthwash respectively. Cytotoxicity of fenugreek extract was studied on five cell lines using MTT and Neutral red assay. A buccoadhesive past was formulated at non-toxic concentration. The patients were followed for the intensity of pain, size of the lesion, erythema and exudate severity on 0, 4, 6, 10 days after treatment. Results From the fourth day of the treatment, the size of the lesion and severity of pain was significantly improved in patients treated with FBP. On the sixth day of the intervention, the erythema level and the size of the ulcer significantly decreased (p Conclusion FBP could improve the most symptoms of RAS in comparison to the control due to the good adhesion of the paste to the surface of the ulcer which forms a protective barrier against more mechanical irritations or infections.