First trimester early‐onset preeclampsia and expanded down syndrome screening: Maternal race/ethnicity adjustments: 924

Abstract

924 First trimester early-onset preeclampsia and expanded down syndrome screening: Maternal race/ ethnicity adjustments Terrence W. Hallahan, David A. Krantz, Hsiao-Pin Liu Eurofins NTD, LLC, Melville, NY OBJECTIVE: To estimate race/ethnic group correction factors for firsttrimester expanded Early-Onset Preeclampsia and Down syndrome screening markers. STUDY DESIGN: Maternal serum data from 12,876 patients in the United States including 2538 with mean arterial pressure (MAP) measurements and 1577 with uterine Artery Doppler pulsatility index (UtAD-PI) was analyzed. Weight-adjusted MoM values using the gestational age specific medians in the Caucasian group were calculated for maternal serum free beta hCG, pregnancy associated plasma protein A (PAPP-A), Alpha-Fetoprotein (AFP), Placental growth factor and Inhibin-A. Pairwise comparisons versus the Caucasian ethnic group were performed using the Wilcoxon test. To account for multiple comparisons, p values of 0.05/35 (<0.0014) were considered significant. RESULTS: Median MOM (P value) Analyte Values for different race/ ethnic Groups