Evaluation of Anterior Segment Parameters in Pseudoexfoliation Disease Using Anterior Segment Optical Coherence Tomography.

Abstract

PURPOSE\nTo compare anterior segment and angle parameters between pseudoexfoliation syndrome(PEX) and pseudoexfoliation glaucoma (PEXG) and normal control subjects by using anterior segment optical coherence tomography (AS-OCT) imaging.\n\n\nDESIGN\ncross- sectional study METHODS: One hundred and two subjects with PEXG, PEX and normal eyes as the control group were recruited from academic referral institution. All subjects underwent complete ophthamologic examination, axial length measurement, AS-OCT imaging (CASIA SS-1000, Tomey). The anterior segment and angle parameters were evaluated.\n\n\nRESULTS\nAfter excluding 4 eyes due to poor imaging of scleral spur, data from 34 eyes with pseudoexfoliation glaucoma (PEXG), 33 eyes with pseudoexfoliation syndrome (PEX) and 31 eyes of normal control subjects were analyzed. Anterior chamber depth (ACD) was significantly shallower in PEXG compared to controls (P< 0.001). The differences in anterior chamber angle parameters were significant among study groups with lower values in PEXG compared to PXS and controls. Lens vault (LV) was lower in PEXG (mean (SD) 0.46 (0.21)) and PEX (0.427 (0.28)) compared to controls (0.305 (0.20)).\n\n\nCONCLUSIONS\nPXG eyes have the narrowest anterior chamber angle parameters. There is a progressive decrease in angle parameters from controls to PXS to PXG. Narrow anterior chamber angle and ACD may have a role in the progression of pseudoexfoliation syndrome to glaucoma. Detection of narrow angle in these patients may help clinician to proper management of the disease.