Anesthetic management for medialization laryngoplasty using concurrent infusions of dexmedetomidine, remifentanil, and propofol versus controls.

Abstract

PURPOSE\nMedialization laryngoplasty (ML)\u202f±\u202farytenoid adduction (AA) surgery poses a unique anesthetic challenge that requires periods of deep sedation and patient cooperation with phonation to assess voice function. The purpose of this study was to assess if the protocolized administration of dexmedetomidine, remifentanil, and propofol (DRP) is associated with reduced procedural duration and administration of other sedating medications.\n\n\nMATERIALS AND METHODS\nThis was a retrospective 2:1 case matched study design; matched on age, sex, body mass index, AA, and surgical revision status. Data was obtained from the electronic medical record of a tertiary referral center. Cases underwent ML\u202f±\u202fAA using DRP. Control subjects underwent surgery ML\u202f±\u202fAA without DRP.\n\n\nRESULTS\n58 DRP cases (43.1% AA) were matched with 116 control patients (44.8% AA). DRP was associated with decreases in fentanyl dose (50 [25, 100] vs. 100 [50, 150] mcg; p\u202f<\u202f0.01), incidence and dose of midazolam (4 [6.9%] vs. 70 [60.3%]; p\u202f<\u202f0.01; 1 [1, 1] vs. 2 [2, 2]; p\u202f<\u202f0.02), operative duration (131\u202f±\u202f33 vs. 160\u202f±\u202f50\u202fmin; p\u202f<\u202f0.01), and anesthetic duration (182\u202f±\u202f35 vs. 219\u202f±\u202f60.3\u202fmin; p\u202f<\u202f0.01). When adjusted for timeline, it was observed that case duration was declining prior to DRP introduction; this trend persisted after DRP introduction. Hypopnea was more common with DRP (14 [24.1%] vs. 7 [6.0%]; p\u202f<\u202f0.01).\n\n\nCONCLUSIONS\nDRP was associated with a substantial decrease in opioid and benzodiazepine administration. A reduction in procedural duration over time was also observed.