Psychometric Characteristics and Validity of the PROMIS® Cancer Function Brief 3D Profile.

Abstract

OBJECTIVE\nTo develop an item response theory (IRT)-calibrated patient-reported outcome measure (the PROMIS® Cancer Function Brief 3D Profile) of physical function, including associations with fatigue and social participation, in cancer rehabilitation patients.\n\n\nDESIGN\nLarge-scale field-testing, graded response model IRT analyses, and multivariate regression analysis.\n\n\nSETTING\nSix cancer rehabilitation clinics associated with cancer centers across the United States.\n\n\nPARTICIPANTS\nAdults treated in outpatient cancer rehabilitation medicine clinics.\n\n\nINTERVENTION\nn/a RESULTS: 616 patients completed 21 items in the initial item pool. Nine items were removed because of comparatively lower information that they provide according to the IRT item calibrations, low item-total correlations and/or bimodal distributions. The remaining items generated a twelve-item short form. Regression analyses determined that the items were responsive to and representative of the patient population across trait ranges and multiple domains/subdomains of function.\n\n\nCONCLUSIONS\nThis psychometric investigation supports the use of the PROMIS® Cancer Function Brief 3D Profile for evaluating function in outpatient cancer rehabilitation patients.