A dimensional approach to the neuronal correlates of anxiety, depression, and perfectionism: A transdiagnostic dissociation of error-related brain activity

Abstract

Transdiagnostic approaches such as the Research Domain Criteria (RDoC) highlight the importance of addressing psychopathological constructs dimensionally, since comorbidity and heterogeneity represent prevalent issues in the available categorical diagnosis. The current study analyses distinct internalizing dimensions of depression and anxiety, and the transdiagnostic feature of perfectionism on the modulation of error-related brain activity (i.e., ERN). A sample of 125 participants completed self-reported measures of anxiety, depression, and perfectionism, and performed two versions of the Flanker Task (performance monitoring and sustained-threat) during an EEG recording. In the broad internalizing dimensions, anxiety predicted increased ERN amplitudes when controlling for the shared variance with depression and perfectionism. The narrower dimensions of anxiety and depression revealed a dissociative effect: cognitive anxiety explained blunted ERN amplitudes, while the physiological signs of anxiety and depression predicted increased amplitudes. For perfectionism, no significant results were found. Exploratory analyses further revealed that the Error Positivity component (Pe) was reduced in anxiety and physiological depression. We conclude that anxiety features emerge as the main explanation for the altered patterns of error monitoring in a transdiagnostic sample. Since anxiety is expected to co-occur with other disorders, the current findings suggest that altered patterns of error monitoring will be a transdiagnostic feature of various internalizing and anxiety-related disorders.