Single nucleotide polymorphism rs10889677 in miRNAs Let-7e and Let-7f binding site of IL23R gene is a strong colorectal cancer determinant: Report and meta-analysis.

Abstract

Single nucleotide polymorphisms (SNPs) in the recognition sites of microRNAs (miRNAs), located at 3 untranslated region (UTR) of mRNAs, interfere with posttranslational gene regulation. Deregulation of genes may contribute to some disease susceptibility including colorectal cancer (CRC). In the present study, in a case-control setup, 167 CRC patients and 161 control subjects were studied for allele and genotype frequency of rs10889677 polymorphism in miRNAs Let-7e and Let-7f binding sites at 3 UTR of IL23R gene using PCR-RFLP assay. Also, related articles were retrieved from MEDLINE, Cochrane review, Google Scholar and Scopus databases for meta-analysis study. According to our results, AA genotype of SNP rs10889677 was significantly correlated with increased risk of CRC (OR\xa0=\xa03.10; 95% CI [1.86-5.18]; P:\xa0<\xa00.001). In a meta-analysis on 10 risk estimates for the CC versus AA genotype, we found an inverse association between CC SNPs and risk of all cancer (OR\xa0=\xa00.59; 95% CI [0.49-0.71]; P\xa0<\xa00.001). In conclusion, our results demonstrate that rs10889677 polymorphism is significantly associated with CRC risk.