Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association | 2021
Hepatobiliary adverse drug reactions associated with remdesivir: The WHO international pharmacovigilance study.
Abstract
Remdesivir has demonstrated clinical benefits in randomized placebo-controlled trials (RCTs) in patients with coronavirus disease 2019 (COVID-19)1-4 and was first approved for COVID-19 patients.5 However, whether remdesivir causes gastrointestinal adverse drug reaction (GI-ADRs) including hepatotoxicity is less clear.1-4,6 Therefore, we aimed to detect a diverse spectrum of GI-ADRs associated with remdesivir using VigiBase, the World Health Organization s international pharmacovigilance database of individual case safety reports.